Development of a single particle ICP-MS method using a high efficiency sample introduction system (APEX TM) for the characterisation of titanium dioxide nanoparticles in foodstuffs |
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| I. Bastardo Fernández, R. Chekri, J. Noireaux, P. Fisicaro, P. Jitaru |
- Abstract:
- This work reports the development of a novel method based on single particle inductively coupled plasma-triple quadrupole mass spectrometry (ICP-QQQMS or ICP-MS/MS) using a high efficiency sample introduction system (HESIS) such as APEXTM for the characterisation of TiO2 (nano)particles (NPs) in food samples. The use of the mass shift detection mode (O2+H2 as a mixture reaction gas) avoids the isobaric interferences of 48Ca isotope hence allowing accurate characterisation of TiO2 NPs in complex matrices such the foodstuffs. APEXTM Ω proved to be an excellent approach to avoid matrix effects from food samples and provided significantly low limits of detection in size (LODsize) compared to the conventional introduction system. In order to avoid the saturation of the detector when detecting large TiO2 particles, the analyses were carried out using the forced analogue detection mode and excellent characterisation of TiO2 NPs in terms of size and concentration was achieved, with LODsize of 12 nm. The new method was applied to the analysis of a selection of foodstuffs, such as candies, sauce, cheese, cakes, etc. purchased in Spain before the ban of the use of TiO2 based additive in the European Union. In all cases, NPs recoveries were assessed based on the comparison with the total Ti level that was also measured by ICPMS in the same samples. This confirms the feasibility of this novel approach using an APEXTM Ω for the accurate characterisation of TiO2 NPs in complex matrices such as the foodstuffs and hence its application to real-life studies.
- Keywords:
- TiO2 nanoparticles, total Ti, single particle ICP-MS/MS, high efficiency sample introduction, foodstuffs system.
- Download:
- IMEKO-TC23-2023-028.pdf
- DOI:
- 10.21014/tc23-2023.028
- Event details
- IMEKO TC:
- TC23
- Event name:
- 7th IMEKOFOODS Conference
- Title:
Worldwide food trade and consumption: quality and risk assessment
- Place:
- Maisons-Alfort/Paris, FRANCE
- Time:
- 25 October 2023 - 27 October 2023